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Falling Hair / Thinning Hair: How To Keep It and Even Grow It Back
Pages: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 Among its other properties as an anti-androgen, spironolactone is a potent competitive inhibitor of DHT at its receptor sites [21]. Therefore, spironolactone effectively prevents DHT from attaching to the receptor sites on the hair follicles [22]. As a result, the follicles no longer atrophy and can mature again to their normal size. And it does so without decreasing the circulating levels of DHT in the body. By comparison, finasteride inhibits the formation of DHT, causing troublesome side effects in many patients. Multiple studies in various medical centers document that spironolactone is effective when applied topically [22].
In studying the anti-androgenic effects of topical spironolactone at the Department of Dermatology at New York University School of Medicine, researchers established that spironolactone concentrations of 0.01% to 5% produced a dose responsive decrease [23]. When both topical 5% spironolactone and topical 5% minoxidil are used daily in the treatment of MPB, the effects of the medications are synergistic. Whereas neither medication alone is particularly effective for the majority of patients, the success of the combination has been experimentally proven. Our own success rate with this formulation has been approximately 75-80%. Our extensive research and development have finally produced a spironolactone lotion which almost totally eliminates the inherent disagreeable smell of spironolactone. In addition to the 5% concentration of spironolactone in the lotion, there are small (1 to 3 mm) vesicular pockets of pure, unsuspended micronized spironolactone powder. This should be spread onto the scalp with one's fingertips to optimize the effects of the application.
Do not combine medications containing spironolactone and minoxidil in the same container. The medications slowly react with each other, resulting in a compromise of their pharmacological activities. However, since it requires many hours for spironolactone and minoxidil to chemically react with each other, they can be consecutively applied to the scalp without compromising one another. Regrowth's 5% Spironolactone Lotion has a shelf life of more than 18 months when kept at normal room temperatures. Next page: Instructions for use. |