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Falling Hair / Thinning Hair: How To Keep It and Even Grow It Back
Pages: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 Spironolactone. It’s been firmly established that alopecia. androgenetica, more commonly known as male pattern baldness or just pattern baldness, is initiated by dihydrotestosterone (DHT) attaching to the receptor sites on the hair follicles [1.2.3.4.]. Genetically, only the follicles on the top of the scalp are encoded with the receptor sites [5.6.24.], which explains why hair follicles along the side of the head and in the back of the head do not atrophy. The attached DHT on the receptor sites is perceived as a foreign body and the immune system begins to destroy the hair follicle, shortening the growth phase and causing the hair shaft to become progressively finer in texture [6]. In extreme cases, only a microscopic vellus hair remains. The good news is that these follicles have the inherent capacity to mature to their former size and thickness.
Encouraged with the success of finasteride to reduce the amount of DHT in the scalp of patients with male pattern baldness (MPB), doctors and scientific researchers took another look at existing medications that are known to act as anti-androgens. There have to be stringent criteria for an anti-androgen that can be used to combat or even reverse pattern alopecia. |